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human normal colon tissue crl1790  (ATCC)


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    ATCC human normal colon tissue crl1790
    Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
    Human Normal Colon Tissue Crl1790, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 647 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy"

    Article Title: PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    doi: 10.1186/s13046-025-03439-y

    Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
    Figure Legend Snippet: Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)

    Techniques Used: Gene Expression, Expressing, Control, Microarray, Irradiation, Quantitative RT-PCR, Cell Culture, Standard Deviation



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    Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
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    Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    Article Title: PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

    doi: 10.1186/s13046-025-03439-y

    Figure Lengend Snippet: Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)

    Article Snippet: Human normal colon tissue CRL1790 and colorectal carcinoma DLD1, HT29, HCT116 and SW48 cell lines were obtained from the American Type Culture Collection (Rockville, Maryland, USA).

    Techniques: Gene Expression, Expressing, Control, Microarray, Irradiation, Quantitative RT-PCR, Cell Culture, Standard Deviation